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Friday, July 31, 2020 | History

4 edition of Chemical modification of proteins found in the catalog.

Chemical modification of proteins

selected methods and analytical procedures

by Alexander N. Glazer

  • 128 Want to read
  • 36 Currently reading

Published by Elsevier Biomedical Press in Amsterdam .
Written in English

    Subjects:
  • Proteins

  • Edition Notes

    StatementA. N. Glazer, R. J. DeLange, D. S. Sigman
    SeriesLaboratory techniques in biochemistry and molecular biology -- vol. 4, part I
    The Physical Object
    Pagination205 S :
    Number of Pages205
    ID Numbers
    Open LibraryOL24932621M
    OCLC/WorldCa610777311

      Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an encyclopedic work describing the many approaches to the site-specific modification of proteins. More than 2, references are cited describing the development of the various reagents. This book Price: $   Selective chemical modification of proteins is enormously useful in a wide range of biological researches, including preparation of protein‐based pharmaceuticals, posttranslational modifications of proteins, visualization of protein activity, modulation of protein function in live cells, and affinity‐based protein : Xi Chen, Stephanie Voss, Yao‐Wen Wu.

    In later years, mechanisms of chemical modification of proteins by ROS/RNS were investigated until the s, notably by E.R. Stadtman, R.L. Levine, R.T. Dean, K.J. Davies, and others, and were.   Therefore, chemical modification with small molecules has attracted much attention as an alternative protein modification technology. In this chapter, several key bioconjugation reactions leading to non-specific chemical modifications and the recent amino acid residue-specific chemical modifications of proteins are first summarized in Sect. : Hiroyuki Nakamura.

    Chemical Modification of Proteins. Gary E. Means, Robert Earl Feeney. Holden-Day, - Organic compounds - pages. 0 Reviews. From inside the book. What people are saying - Write a review. We haven't found any reviews in the usual places. Contents. MODIFICATIONS TO CHANGE PROPERTIES. 3. "Christopher Walsh, an acclaimed scientist, has written yet another outstanding book. It surveys the vast field of chemical modifications that proteins undergo in living cells. The book's depth of coverage and clarity of exposition will make it an indispensable text for both students and active researchers.".


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Chemical modification of proteins by Alexander N. Glazer Download PDF EPUB FB2

Chemical modification of an existing protein can be useful for probing structure, function and stability relationships of proteins.

Chemical modification can serve as a replacement or complementary method to recombinant DNA technology for improving the properties of a protein (Table ).This may have particular benefit for proteins targeted for commercial exploitation due to the increasing.

Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations.

Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Chemical modification in biochemistry. Main Article: [insert main article link] In biochemistry, chemical modification is the technique of anatomically reacting a protein or nucleic acid with a reagent or reagents.

Obtaining laboratory information through chemical modification which can be utilized to. Additional Physical Format: Online version: Means, Gary E.

Chemical modification of proteins. San Francisco, Holden-Day [] (OCoLC) Document Type. Chemical Modification of Proteins (Laboratory Techniques in Biochemistry & Molecular Biology) (Vol 4) 1st Edition by R.

DeLange (Author), D. Sigman (Contributor) › Visit Amazon's D. Sigman Page. Find all the books, read about the author, and more.

See search results for this author Cited by: Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.

Highlights. The basic organic chemistry of the modification proteins Cited by: 4. The Proteins, Third Edition, Volume II is a three-chapter text that highlights the application of methods of organic chemistry to the study of protein structure.

Chapter 1 reviews the chemical modification of proteins by group- and site-specific reagents. Book Description. The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry.

Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins.

The chemical modification of proteins is an important tool for probing natural systems and synthesizing novel conjugates. Here, Spicer and Davis review the merits and limitations of the most Cited by: ISBN: X OCLC Number: Description: viii, pages: illustrations ; 21 cm.

First published inChemical Reagents for Protein Modification, 2nd Edition provides a unique combination of theoretical and practical considerations for the use of chemical reagents for site-specific modification of proteins. The book is divided into three sections, with the first section describing general techniques, including Book Edition: 1st Edition.

Purchase Chemical Modification of Proteins, Volume 4 - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1.

Protein Post-Translational Modification. Protein modifications performed by “extra-translational” processes. Cannot be definitively predicted from DNA sequence. Can involve very complex systems of enzymes. In some cases, “consensus” sites of modification can be identified.

Ubiquitous in eukaryotes. Frequently critical for:File Size: KB. The deteriorative type includes the Maillard reaction and the alkaline degradations leading to compounds like lysinoalanine. Although the intentional chemical modification of food proteins is currently applied to only a limited extent, it offers opportunities for improving food proteins and extending their availability from nonconventional sources.

The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins.

This groundbreaking work is part of the. Introduction. The chemical modification of peptides or proteins prior to MS-analysis is generally carried out for any of three purposes: (1) to attach an affinity handle to purify a subset of the proteome, (2) to incorporate stable isotope labels for relative quantification of two or more samples, and/or (3) to modify the physiochemical properties of peptides and proteins to improve them as Cited by: 7.

Unlike chemical modification of residues, which often is reversible, processing of some proteins causes irreversible changes that alter their activity. In the most common form of processing, residues are removed from the C- or N-terminus of a polypeptide by cleavage of the peptide bond in a reaction catalyzed by by: 1.

Offers discussions on the chemical and physicochemical modification of proteins for the enhancement of surface activity and functional properties in a variety of systems.

The volume provides examples of specific applications of modified proteins in gelation, emulsification, foaming, adsorption and surface tension reduction for use in the food Cited by: Book Description. Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.

Highlights. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified.

Regulation of Protein Surfaces Through Posttranslational Modification. Cite this entry as: () Chemical Modification of Proteins.

In: Roberts G.C.K. (eds) Encyclopedia of Biophysics.First published inChemical Reagents for Protein Modification, 2nd Edition provides a unique combination of theoretical and practical considerations for the use of chemical reagents for site-specific modification of proteins.

The book is divided into three sections, with the first section desc.Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein ns are synthesized by ribosomes translating mRNA into polypeptide chains, which may then undergo PTM to form the mature protein product.

PTMs are important components in cell signaling, as for example when prohormones are converted to hormones.